Abstract
This systematic review and meta-analysis examined monkeypox infection outcomes among immunocompromised populations in Sub-Saharan Africa, with particular focus on clinical implications for Ghana and neighboring countries. Following PRISMA guidelines, the study analyzed 36 peer-reviewed articles from 1970-2024, employing comprehensive data visualization and statistical analysis techniques.
Key findings revealed significant correlations between immune status and disease outcomes, with HIV+ patients showing 2.8 times higher risk of severe outcomes [32]. Healthcare access disparities substantially impact treatment efficacy, with urban centers achieving 75-82% access rates compared to 38-45% in rural areas [25, 26]. Clinical progression analysis demonstrated extended recovery periods for immunocompromised patients, with symptom resolution taking up to 8 weeks compared to 4 weeks in immunocompetent individuals [16, 17].
Recommendations include implementing immune status-specific treatment protocols, establishing rapid response systems for rural areas, and developing specialized care pathways for immunocompromised patients. For Ghana and other Sub-Saharan countries, priorities include strengthening rural healthcare infrastructure, enhancing surveillance systems, and implementing targeted prevention strategies for vulnerable populations [2, 3, 32]. These findings provide crucial guidance for healthcare practitioners managing monkeypox in resource-limited settings.
Keywords
Ayeh, M. A., Cofie, K., Mensah, G. S., Amo-Kodieh, F., & Kyeremeh, P. (2025). Monkeypox Infection: Risk Assessment and Clinical Outcomes Among Immunocompromised Populations in Sub-Saharan Africa:: A Systematic Review and Meta-analysis. Ghana Journal of Nursing and Midwifery, 1(4), 107-124. https://doi.org/10.69600/gjnmid.2024.v01.i04.107-124
Ayeh, Michael Adu, et al. “Monkeypox Infection: Risk Assessment and Clinical Outcomes Among Immunocompromised Populations in Sub-Saharan Africa:: A Systematic Review and Meta-analysis.” Ghana Journal of Nursing and Midwifery, vol. 1, no. 4, 2025, pp. 107-124. https://doi.org/10.69600/gjnmid.2024.v01.i04.107-124.
Ayeh, Michael Adu, et al. “Monkeypox Infection: Risk Assessment and Clinical Outcomes Among Immunocompromised Populations in Sub-Saharan Africa:: A Systematic Review and Meta-analysis.” Ghana Journal of Nursing and Midwifery 1(4) (2025): 107-124. https://doi.org/10.69600/gjnmid.2024.v01.i04.107-124
Ayeh, M. A., Cofie, K., Mensah, G. S., Amo-Kodieh, F. and Kyeremeh, P. (2025) ‘Monkeypox Infection: Risk Assessment and Clinical Outcomes Among Immunocompromised Populations in Sub-Saharan Africa:: A Systematic Review and Meta-analysis’, Ghana Journal of Nursing and Midwifery, 1(4), pp. 107-124. doi:10.69600/gjnmid.2024.v01.i04.107-124.
Ayeh MA, Cofie K, Mensah GS, Amo-Kodieh F, Kyeremeh P. Monkeypox Infection: Risk Assessment and Clinical Outcomes Among Immunocompromised Populations in Sub-Saharan Africa:: A Systematic Review and Meta-analysis. GJNMID. 2025;1(4):107-124. doi:10.69600/gjnmid.2024.v01.i04.107-124
M. A. Ayeh, K. Cofie, G. S. Mensah, F. Amo-Kodieh, and P. Kyeremeh, “Monkeypox Infection: Risk Assessment and Clinical Outcomes Among Immunocompromised Populations in Sub-Saharan Africa:: A Systematic Review and Meta-analysis,” Ghana Journal of Nursing and Midwifery, vol. 1, no. 4, pp. 107-124, 2025, doi: 10.69600/gjnmid.2024.v01.i04.107-124.
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